Lupus erythematosus(SLE or lupus) is a chronic inflammatory disease. Lupus is called a multisystem disease because it can affect many different tissues and organs in the body. Lupus can affect many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels, and brain. There are three major types of lupus first is Systemic lupus erythematosus (SLE) is the type of lupus with which most people are familiar. Second is Lupus that is limited to the skin is called discoid lupus erythematosus and Last is Drug-induced lupus is triggered by taking a medication. It usually goes away a few weeks or months after the patient stops taking the drug. Inflammation of various parts of the heart may occur as pericarditis endocarditis. Chest pain and arrhythmias may result from these conditions. The most common symptoms include skin rashes and arthritis, often accompanied by fatigue and fever. Lupus is one of many disorders of the immune system known as autoimmune diseases. Immune system turns against parts of the body it is designed to protect. This leads to inflammation and damage to various body tissues. Sometimes lupus can cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system.
Genetic factors increase the tendency of developing autoimmune diseases. Symptoms vary from person to person, and may come and go. The condition may affect one organ or body system at first. Other symptoms include fever, sun sensitivity with the development of a rash or flare, hair loss, mouth or nose ulcers, chest pains caused by breathing, weight loss or gain, leg swelling, and seizures. The disorder typically develops in people in their twenties and thirties. SLE is more common in certain ethnic groups, particularly in blacks and Asians, who also tend to be more severely affected. If inflammation occurs in the heart or lungs, you may experience chest pain or shortness of breath. Lupus can also cause changes in the number and type of blood cells in the bloodstream. Lupus is more common in women than men, and its peak incidence is after puberty. Normally the immune system protects the body by fighting off bacteria, viruses, and other foreign invaders. It is affect the skin, joints, kidneys, lungs, nervous system.
Causes of Lupus Erythematosus
Common causes of Lupus Erythematosus
- Environmental triggers.
- Drug reactions.
Symptoms of Lupus Erythematosus
Common Symptoms of Lupus Erythematosus
- Skin rash.
- Muscle aches.
- Swollen glands Lack of appetite.
- Weight loss.
Treatment of Lupus Erythematosus
Common Treatment of Lupus Erythematosus
- Medications: aspirin and other anti-inflammatory drugs, NSAIDs, Antimalarial drugs, Corticosteroids, Immunosuppressants
- Conservative options include nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen ( Motrin, Advil) and naproxen (Naprosyn) and anti-malarial medications such as hydroxychloroquine (Plaquenil).
- Circumstances might involve high dose corticosteroids such as prednisone ( Deltasone ) and
- Other immunosuppressive drugs such as azathioprine (Imuran) cyclosporine (Neoral, Sandimmune). Recently mycophenolate mofetil has been used to treat severe lupus kidney disease.
- People with sun-induced rashes should always wear a high SPF lotion that blocks both UVA and UVB types of ultraviolet light.
- Hydroxychloroquine (Plaquenil) is an antimalarial medication found to be particularly effective for SLE patients with fatigue, skin, and joint disease.