|
Genetic Name
Norvir
Brand Names
Ritonavir
General Information
Norvir is an anti-HIV medication. HIV is a retrovirus which causes acquired immunodeficiency syndrome. It is upshotted immune system and nerve system. HIV chiefly defiles vital cells in the human immune system such as helper T cells (specifically CD4 + T cells), macrophages and dendritic cells. Norvir is one of the two drugs in Kaletra. Kaletra contains the protease inhibitor lopinavir and small amounts of Norvir. It is in a classification of HIV medications called protease inhibitors (PIs).
Norvir is inadvisabaled with amiodarone, astemizole, bepridil, cisapride, dihydroergotamine, ergonovine, ergotamine, flecainide, methylergonovine, midazolam, pimozide, propafenone, quinidine, terfenadine, and triazolam. Norvir prevents T-cells which have been infected with HIV from producing new HIV. HIV-1 insulates with reduced vulnerability to ritonavir have been selected in vitro . Genotypic analysis of these isolates showed mutations in the HIV protease gene at amino acid positions. Ritonavir is a peptidomimetic inhibitor of both the HIV-1 and HIV-2 proteases. Inhibition of HIV protease abdicates the enzyme incapable of processing the gag-pol polyprotein precursor which leads to production of non-infectious immature HIV particles.
Most common side effects with full dose Norvir are associated to the stomach-intestinal and nervous systems. Norvir has been approbated for use in children 1 month of age and older. As the child grows, the dose will increase. Occassionally taking more than one medication can cause drug interactions. Due to the way Norvir is metabolized, or processed in the body, Ritonavir pharmacokinetics have not been studied in patients with renal deficiency, however, since renal clearance is negligible, a decrease in total body riddance is not expected in patients with renal insufficiency. The dose will based on the child's body size. The dose should be between 350 to 400mg per square meter of body area, twice a day.
Norvir, even if low doses are used with another protease inhibitor, should be taken with a meal or light snack. Take with meals, superiorly a high fat meal. Capsules need to be refrigerated. Norvir improves or “boosts” the effectiveness of some other PIs by increasing their levels in your blood. Taking Norvir makes it eventual to take a lower dose of the other PIs, which lets you take fewer pills and may result in fewer and less severe side effects.
Side effects of Norvir
Common side effects norvir are related to stomach-intestinal and nervous systems.
- Stomach-intestinal pain.
- Nausea.
- Vomiting.
- Diarrhea.
- Loss of appetite.
- Altered taste sensation.
- Throat irritation or soreness.
Norvir Dosage
- The dose of these medicines will be different for different patients.
- Adult- Six 100-mg capsules (twice a day).
Warnings and precautions before taking Norvir
If you have kidney disease or liver disease do not take this drugs. Hepatic transaminase elevations surpassing 5 times the upper limit of normal, clinical hepatitis, and jaundice have occurred in patients receiving NORVIR alone or in combination with other antiretroviral drugs. Drug interaction study in wholesome subjects has shown that ritonavir significantly increases plasma fluticasone propionate exposures, resulting in significantly decreased serum cortisol concentrations. Norvir should not be given to patients withdiscerned hypersensitivity to ritonavir or any of its ingredients. Mostly allergic reactions ranging.
|
|
