Navelbine is a chemotherapy drug used in the treatment of cancer. Navelbine derives from a plant in the periwinkle family. Vinorelbine mostly treated breast cancer and non-small-cell lung cancer. Navelbine belongs to the family of drugs called plant alkaloids. Navelbine meddles with the growth of rapidly dividing cells, like cancer cells, and eventually causes cell death. Navelbine may be used alone or used in coalition with other chemotherapy agents. Navelbine tartrate is a semi-synthetic vinca alkaloid with antitumor activity. The vinca alkaloids are structurally uniform compounds comprised of 2 multiringed units, vindoline and catharanthine.
Navelbine undergoes corporeal hepatic elimination in humans, with large amounts recovered in feces after intravenous administration to humans. Two metabolites of vinorelbine have been categorised in human blood , plasma, and urine; vinorelbine N-oxide and deacetylvinorelbine. Deacetylvinorelbine has been corroborated to be the primary metabolite of vinorelbine in humans, and has been shown to possess antitumor activity similar to vinorelbine. Vinorelbine using certain chromatographic analytical methodology showed that 10.9% ± 0.7% of a 30 mg/m2 intravenous dose was excreted unchanged in the urine.
Navelbine is given by injection only into a vein (intravenously-IV) by a healthcare professional. It is typically given over 6-10 minutes, once a week. Side effects of Vinorelbine are vomiting, fatigue, constipation, diarrhea, tingling of the feet or hands; mild, reversible hair loss and muscle aches. A very critical allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a severe allergic reaction may include: rash, itching, swelling, acute dizziness, trouble breathing. This medication should not be used if you have certain medical situations. Use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports to lower the risk of getting cut, bruised or injured.
Navelbine can sometimes cause a serious skin reaction which seems likes a severe sunburn when given after radiation treatment (radiation recall). The reaction generally grows on the skin area previously treated with radiation within days to months after vinorelbine treatment. This drug may make you dizzy; use caution tempting in activities requiring alertness such as driving or using machinery. Breast-feeding while using this drug is not suggested. Limit alcoholic beverages. This drug is not advised for use during pregnancy. It may cause harm to an unborn baby. If you take overdose contact your local poison and emergency room immediately.
Side effects of Navelbine
- Tingling of the feet or hands.
- Hair loss.
- Muscle aches.
- Vinorelbine may be given by injection into a vein (intravenously) through a fine tube (cannula).
- It is usually given over 6-10 minutes, once a week. Use at least 250ml normal saline to flush the vein immediately after administration.
Warnings and precautions before taking Navelbine
For both men and women: Do not conceive a child (get pregnant) while taking Navelbine. Barrier methods of contraception, such as condoms, are prescribed. This drug may make you dizzy; use caution engaging in activities requiring wariness such as driving or using machinery. Limit alcoholic beverages. Do not breast feed while taking Navelbine. Avoid contact sports or activities which could cause injury. Vinorelbine is not prescribed for use during pregnancy. Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing. To minimize nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals. If overdose is suspected, consult your local poison control center or emergency room immediately. Symptoms of navelbine overdose may include severe constipation, weakness, or mouth sores; unusual fatigue; easy bleeding or bruising.