Nafcillin is an antibiotic in the penicillin cluster of drugs. Nafcillin kills specific bacteria that cause infection, or belays their growth. Nafcillin can be given either orally or by injection. Nafcillin Injection, USP is a sterile injectable product containing nafcillin that is added as Nafcillin Sodium, USP, a semisynthetic penicillin emanated from the penicillin nucleus, 6-aminopenicillanic acid. It combats bacteria in your body. Penicillins are used to treat bacterial infections in many various parts of the body. They are occassionally given with other antibacterial medicines (antibiotics). In comparison to the other penicillinase-resistant penicillins, only about 30% of nafcillin is excreted as unchanged drug in the urine of normal volunteers, and most within the first six hours.
Nafcillin binds to serum proteins, basically albumin . The extent of protein binding reported for nafcillin is 89.9 ± 1.5%. The penicillinase-resistant penicillins are broadly distributed in different body fluids, including bile, pleural, amniotic and synovial fluids. With normal doses trivial concentrations are found in the aqueous humor of the eye.
Nafcillin is contain 6-aminopenicillanic acid with a side chain affixed to the 6- amino group. The penicillin nucleus is the chief structural requisite for biological activity. A change in the nucleus will result to a decrease in anti-bacterial activity. High nafcillin CSF levels have been obtained in the vicinity of inflamed meninges.
Nafcillin treats many types of infections of the skin, central nervous system, heart, brain, bones, respiratory tract, sinuses, and urinary tract. Take nafcillin 1 to 2 hours before or at least 2 hours after eating; taking it with food can make it less effective. Nafcillin have many side effects that are Nausea and vomiting, Diarrhea, Clostridium difficile, Abdominal pain, Yeast infections ( thrush ) affecting the mouth and tongue. Do not use the solution if it is smutted, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
Side effects of Nafcillin
- Clostridium difficile.
- Abdominal pain.
- Yeast infections ( thrush ).
- The dose of these medicines will be different for different patients.
- Adults-1000 mg twice a day every twelve hours for fourteen days, along with the two other medicines, clarithromycin and lansoprazole
- Children- Use and dose must be determined by your doctor.
Warnings and precautions before taking Nafcillin
Avoid drinking alcohol. It can increase stomach exasperation caused by nafcillin. Antibiotic medicines can cause diarrhea, that may be a symptom of a new infection. Penicillins are secreated in human milk. Caution should be exertioned when penicillins are administered to a nursing woman. Keep out of the reach of children in a container which small children cannot open. Penicillin should be used withprudence in individuals with histories of significant allergies and/or asthma. Seek emergency medical attention if you have used too much of this medicine. Signs of a nafcillin overdose may comprise muscle spasms or weakness, muscle pain or twitching, numbness or tingly feeling, confusion, feeling light-headed, fainting, and seizure (black-out or convulsions).