Metformin is an anti-diabetic drug. Metformin is an oral diabetes medicine which helps regulare blood sugar levels. It is also being used progressively in polycystic ovarian syndrome. Metformin hydrochloride is not chemically or pharmacologically associated to any other classes of oral antihyperglycemic agents. Metformin main use for metformin is in the treatment of diabetes mellitus type 2, mainly when this accompanies obesity and insulin resistance. Metformin helps to manage the amount of glucose (sugar) in your blood. It reduces the amount of glucose you absorb from your food and the amount of glucose made by your liver.
Metformin also increases your body's retroaction to insulin, a natural substance that controls the amount of glucose in the blood. GLUCOPHAGE XR includes a dual hydrophilic polymer matrix system. Metformin hydrochloride is combined with a drug release controlling polymer to form an "inner" phase, that is then integrated as discrete particles into an "external" phase of a second polymer. After administration, fluid from the gastrointestinal (GI) tract penetrates the tablet, causing the polymers to hydrate and swell.
There are 3 main problems related with this medication Premary is lactic Acidosis. Second is B-12 Deficiencyand last is contrast agent. GLUCOPHAGE XR works longer in your body. Components of the tablet may sometimes stay intact during GI transit and will be eliminated in the feces as a soft, hydrated mass.
Other most-commonly prescribed oral diabetes drugs, the sulfonylureas, metformin monotherapy will not persuade hypoglycemia Metformin pharmacokinetic parameters did not differ significantly between normal subjects and patients with type 2 diabetes when analyzed according to gender (males = 19, females = 16). High blood sugar can be reduced by diet and exercise, by a number of medicines taken by mouth, and by insulin shots. Prior you take GLUCOPHAGE or GLUCOPHAGE XR, try to control your diabetes by exercise and weight loss. The most common side effect of metformin is gastrointestinal upset, comprising diarrhea, cramps, nausea and vomiting. Many drugs can influence your blood sugar levels, making it more difficult to control your blood sugar.
Side effect of Metformin
- Gastrointestinal upset.
- The dose of these medicines will be different for different patients.
- Adult-metformin usually is begun at a dose of 500 mg twice a day or 850 mg once daily.
- Children- 10-16 years of age, the starting dose is 500 mg twice a day.
Warnings and precautions before taking Metformin
Limit alcohol while using this medication to lower your chance of lactic acidosis. Kidney function diminishes as you grow older. This medication is removed by the kidneys. Hence, elderly people may be a greater risk for side effects such as lactic acidosis or low blood sugar while using this drug. This medication can cause variations in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Breast-feeding is not advised while using this drug. If overdose is suspected, consult your local poison control center or emergency room immediately. Signs of metformin overdose may include: rapid breathing, severe drowsiness, slow/irregular heartbeat.