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Methenamine Medication - Uses and Side Effects


Metronidazole Topical
Niferex Elixir

Genetic Name

  • Mandelamine

Brand Names

  • Hiprex.

General information

Mandelamine belongs to the genealogy of medicines called anti-infectives. Mandelamine is a urinary antiseptic. It works by concentrating in the urine as formaldehyde, that kills bacteria in the urine. This medication is an antibiotic used to treat infection of the urinary tract (kidney, bladder).

Mandelamine is constituent, acid urine hydrolyzed to ammonia and to the bactericidal agent formaldehyde. There is identically effective antibacterial activity against both gram-positive and gram-negative organisms, since the antibacterial action of mandelic acid and formaldehyde is nonspecific. Mandelic acid is excreted by both glomerular filtration and tubular excretion. Methenamine is ineffectual in some infections with P. vulgaris and urea-splitting strains of P. aeruginosa and A. aerogenes. Since urea-splitting strains may augment the pH of the urine, particular attention to supplementary acidification, with agents such as ascorbic acid, is required.

Methenamine may cause stomach upset, loss of appetency, diarrhea, nausea, or headache. Methenamine should not be used in patients who are hypersensitive to the drug. Evacuation of bacteriuria associated with pyelonephritis, cystitis and other urinary tract infections; also those neurologic diseases leading to an infected residual urine.

Methenamine salts of Mandelamine should be neglected in patients with gout because these drugs may precipitate urate crystals in their urine. A analogous situation may arise in patients with a predisposition to the formation of uric acid stones. Dysuria may develop (usually at higher than recommended dosage) with the use of methenamine mandelate. This can be managed by reducing the dosage and the acidification. Signs of overdosage with methenamine may include gastrointestinal insanity and urinary tract irritation.

Side effect of Mandelamine

  • Nausea.
  • Upset stomach.
  • Itching.
  • Difficulty breathing.
  • Tightness in the chest.
  • Swelling of the mouth, face, lips, or tongue.

Mandelamine Dosage

  • The dose of these medicines will be different for different patients.
  • Adults: 2 tablets 4 times a day.
  • Children over 5 years: 1 tablet 4 times daily. Children under 5 years: 250 mg/14 kg 4 times daily.

Warnings and precautions before taking Mandelamine

Mandelamine should be used only when clearly required during pregnancy. Wrangle the risks and benefits with your doctor. Dysuria may occur (usually at higher than prescribed dosage) with the use of Mandelamine mandelate. This can be controlled by lessening the dosage and the acidification. The patient should be directioned to take no other antibiotics for urinary tract infection while taking Mandelamine. Methenamine salts of Mandelamine should be avoided in patients with gout as these drugs may precipitate urate crystals in their urine. Hallmarks of overdosage with Mandelamine may include gastrointestinal disturbances and urinary tract irritation. Call your local poison control center or emergency room immediately.